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| Player | Games | AVG | OBP | SLG |
| Ty Cobb | 3034 | .366 | .433 | .512 |
| Rogers Hornsby | 2259 | .358 | .434 | .577 |
| Joe Jackson | 1332 | .356 | .423 | .517 |
| Ed Delahanty | 1837 | .346 | .411 | .505 |
| Tris Speaker | 2789 | .345 | .428 | .500 |
| Ted Williams | 2292 | .344 | .482 | .634 |
| Babe Ruth | 2503 | .342 | .474 | .690 |
| Harry Heilmann | 2147 | .342 | .410 | .520 |
| Dan Brouthers | 1673 | .342 | .423 | .519 |
| Lou Gehrig | 2164 | .340 | .447 | .632 |
| Todd Helton | 1930 | .324 | .424 | .555 |
| Albert Pujols | 1558 | .331 | .426 | .624 |
| Stan Musial | 3026 | .331 | .417 | .559 |
| Jimmie Foxx | 2317 | .325 | .428 | .609 |
| Manny Ramirez | 2297 | .313 | .411 | .586 |
| Larry Walker | 1988 | .313 | .400 | .565 |
| Hank Greenberg | 1394 | .313 | .412 | .605 |
| Edgar Martinez | 2055 | .312 | .418 | .515 |
| Frank Thomas | 2322 | .301 | .419 | .555 |
| Mel Ott | 2730 | .304 | .414 | .533 |
| Chipper Jones | 2261 | .306 | .405 | .536 |
| Lefty O'Doul | 970 | .349 | .413 | .532 |
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